ok I take oxycodone/ Percocet and have for several years, I have never been able to take hydrocodone or loratabs because I have a highly allergic reaction to codeine. Codeine is an opioid narcotic that binds to μ opioid receptors. It is used for blocking moderate to moderately-severe pain. It is also prescribed for cough suppression and chronic diarrhea. Below is an overview of codeine vs. oxycodone, along with answers to questions like “is codeine in oxycodone.” What is Codeine? Relative to other opioids, codeine is considered somewhat mild, and it’s less potent than many of the other prescription opioid pain relievers on the market. I have been taking percocet 5-325mgs for 6 yrs, I had to go to a pain management doctor and show him all of my medications after explaining to him that I take 6 oxycodone percocet a day he told me that there was no way I should be taking that medication if I was allergic to coating because oxycodone percocet has codeine in it and I told him. Oxycodone and codeine are both medications used for pain relief that belong to the family of drugs known as opioid analgesics. Both drugs share many structural and functional similarities, but they also differ in key ways, which cause them to have related, but non-identical, medical uses. A few of the metabolites of oxycodone have also been found to be active as MOR agonists, some of which notably have much higher affinity for (as well as higher efficacy at) the MOR in comparison. They sound similar, are they related? Yes and no. They are both used to treat pain, and share the same molecular backbone (they have similar structures), along with two other important opiates, morphine and thebaine. No. It contains oxycodone instead, and that is a stronger narcotic. Tylenol III with codeine is the combination drug that contains codeine. No. Both oxycodone and codeine treat pain. Patients will take oxycodone when they have moderate to severe pain. One option for oxycodone is an extended-release tablet, which patients only need to take once a day. Oxycodone dosage. The usual starting dose using immediate release oxycodone tablets is 5 to 30 mg every 4 to 6 hours. Patients who have never received opioids should start with 5-15 mg every 4 to 6 hours.